ANGIOGENESIS
A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis
ZJ Su et al
PNAS 2004;101: 12212-12217
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BIO- & TISSUE ENGINEERING
Natural Product Synthesis Special Feature: The art and science of constructing the molecules of nature
KC Nicolaou
PNAS 2004;101: 11928
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Natural Product Synthesis Special Feature: The essence of total synthesis
KC Nicolaou and SA Snyder
PNAS 2004;101: 11929-11936
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Natural Product Synthesis Special Feature: Prospects for total synthesis: A vision for a totally synthetic vaccine targeting epithelial tumors
SJ Keding & SJ Danishefsky
PNAS 2004;101: 11937-11942
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Energetic clues to pathways to biomineralization: Precursors, clusters, and nanoparticles
A Navrotsky
PNAS 2004;101: 12096-12101
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Nucleic acid transport through carbon nanotube membranes
I-C Yeh and G Hummer
PNAS 2004;101: 12177-12182
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Sequential shape-and-solder-directed self-assembly of functional microsystems
W Zheng et al
PNAS 2004;101 12814-12817
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CYTOKINES-GROWTH FACTORS
In different organisms, the mode of interaction between two signaling proteins is not necessarily conserved
S-Y Park et al
PNAS 2004;101 11646-11651
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GENE THERAPY-TRANSFECTION
Gene Targeting: Attention to Detail
B. Vanhaesebroeck et al
Cell 118: 274
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GENOMICS, PROTEOMICS
The mouse kinome: Discovery and comparative genomics of all mouse protein kinases
S Caenepeel et al
PNAS 2004;101 11707-11712
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A proteomic approach for the discovery of protease substrates
AJ Bredemeyer et al
PNAS 2004;101 11785-11790
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Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture
E Durr et al
Nature Biotechnology 22, 985 - 992 (2004)
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The Knockout Mouse Project
The Comprehensive Knockout Mouse Project Consortium
Nature Genetics 36, 921 - 924 (2004)
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IMAGING TECHNOLOGY
Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals
KE Luker et al
PNAS 2004;101: 12288-12293
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Imaging inflammation of the pancreatic islets in type 1 diabetes
MC Denis et al
PNAS 2004;101 12634-12639
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INFLAMMATION, IMMUNE RESPONSES
Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells
C Lu et al
PNAS 2004;101 11767-11772
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Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury
R Bertini et al
PNAS 2004;101 11791-11796
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Determination of the Critical Concentration of Neutrophils Required to Block Bacterial Growth in Tissues
Y Li et al
J. Exp. Med. 2004;200 613-622
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ISCHEMIA-HYPOXIA-REPERFUSION
Inhibition of Phospholipase C Improves Post-Ischemic Recovery in Isolated Rat Heart
G Asemu et al
Am J Physiol Heart Circ Physiol 10.1152/ajpheart.00506.2004
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Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury
AS Pachori et al
PNAS 2004;101: 12282-12287
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KERATINOCYTES, KERATINOCYTE-FIBROBLAST INTERACTION, EPIDERMIS
Epithelial-Mesenchymal Transitions: Twist in Development and Metastasis
Y. Kang and J. Massagué
Cell 118: 277
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Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane
KR Groot et al
J. Cell Biol. 2004 166 (5)
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Bax Activation and Induction of Apoptosis in Human Keratinocytes by the Protein Kinase C- Catalytic Domain
LA Sitailo et al
J Invest Dermatol 2004;123 434-443
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Ligation of the 4 Integrin Triggers Adhesion Behavior of Human Keratinocytes by an "Inside-out" Mechanism
S Kippenberger et al
J Invest Dermatol 2004;123 444-451
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The Osmolyte Strategy of Normal Human Keratinocytes in Maintaining Cell Homeostasis
U Warskulat et al
J Invest Dermatol 2004;123 516-521
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Dynamics of Keratinocytes in Vivo using 2H2O Labeling: A Sensitive Marker of Epidermal Proliferation State
EA Hsieh et al
J Invest Dermatol 2004;123 530-536
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MISCELLANEOUS
Cellular and Genetic Analysis of Wound Healing in Drosophila Larvae
MJ Galko & MA Krasnow
PLoS-Biology 2: 1114
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Tissue-specific codon usage and the expression of human genes
JB Plotkin et al
PNAS 2004;101 12588-12591
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Towards sound epistemological foundations of statistical methods for high-dimensional biology
T Mehta et al
Nature Genetics 36, 943 - 947 (2004)
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Nuclear reprogramming: A key to stem cell function in regenerative medicine
J Pomerantz & HM Blau
Nat Cell Biol. 2004 Sep;6(9):810-6
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MMPs-Proteases
Activation of MMP-2 in Response to Vascular Injury is mediated by Phosphatidylinositol 3-Kinase-dependent Expression of MT-1 MMP (MMP-14)
P Zahradka et al
Am J Physiol Heart Circ Physiol 10.1152/ajpheart.00230.2004
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Wound Healing in Membrane-Type-1 Matrix Metalloproteinase-Deficient Mice
U Mirastschijski et al
J Invest Dermatol 2004;123 600-602
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REGENERATION, STEM CELLS, DEVELOPMENT, PHENOTYPE
Epithelial Stem Cells: Stepping out of Their Niche
AM Christiano
Cell 118: 530
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Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche
C Blanpain, et al
Cell 118: 635
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Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone
H Sumiyoshi et al
J. Cell Biol. 2004 166 (4)
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Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation
M Dominici et al
PNAS 2004;101 11761-11766
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Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex
S. Kelly et al
PNAS 2004;101 11839-11844
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Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut
M Fu et al
J. Cell Biol. 2004 166 (5)
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Unraveling the Molecular Basis for Regenerative Cellular Plasticity
SJ Odelberg
PLoS-Biology 2: 1068
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The Regenerative Plasticity of Isolated Urodele Myofibers and Its Dependence on Msx1
A Kumar et al
PLoS-Biology 2: 1168
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Comparative Analysis of Armadillo Family Proteins in the Regulation of A431 Epithelial Cell Junction Assembly, Adhesion and Migration
SV Setzer et al
J Invest Dermatol 2004;123 426-433
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Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning
S Ahn and AL Joyner
Cell 118: 505
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Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities
BD Harfe et al
Cell 118: 517
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Identification of 315 genes essential for early zebrafish development
A Amsterdam et al
PNAS 2004;101 12792-12797
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SCARRING-FIBROSIS
Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation
S Shaunak et al
Nature Biotechnology 22, 977 - 984 (2004)
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Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis
Lee et al.
J. Exp. Med..2004; 200: 377-389.
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SIGNAL TRANSDUCTION
MAP Kinase-Mediated Stress Relief that Precedes and Regulates the Timing of Transcriptional Induction
M. Proft and K. Struhl
Cell 118: 351
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Structural Basis of Heteromeric Smad Protein Assembly in TGF-ß Signaling
BM Chacko et al
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STRESS
Degradation of Misfolded Proteins Prevents ER-Derived Oxidative Stress and Cell Death
CM Haynes et al
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